Tuesday, May 22, 2012

1205.4580 (Jens-Uwe Sommer et al.)

Critical adsorption controls translocation of polymer chains through
lipid bilayers and permeation of solvent
   [PDF]

Jens-Uwe Sommer, Marco Werner, Vladimir A. Baulin
Monte Carlo simulations using an explicit solvent model indicate a new pathway for translocation of a polymer chain through a lipid bilayer. We consider a polymer chain composed of repeat units with a given hydrophobicity and a coarse-grained model of a lipid bilayer in the self-organized liquid state. By varying the degree of hydrophobicity the chain undergoes an adsorption transition with respect to the lipid bilayer. Close to the transition point, at a properly balanced hydrophobicity of the chain, the membrane becomes transparent with respect to the chain. At the same time the solvent permeability of the bilayer is strongly increased in the region close to adsorbed chain. Our results indicate that the critical point of adsorption of the polymer chain interacting with the fluctuating lipid bilayer could play a key role for the translocation of molecules though biological membranes.
View original: http://arxiv.org/abs/1205.4580

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