Farnoush Farahpour, Azadeh Maleknejad, Fathollah Varnik, Mohammad Reza Ejtehadi
Deformation of single stranded DNA before reaching the pore in translocation process is investigated. By solving the Laplace equation in a suitable coordinate system and with appropriate boundary conditions, an approximate solution for electric field inside and outside of a narrow pore is obtained. With an analysis based on "electrohydrodynamic equivalence" we determine the possibility of extension of a charged polymer due to the presence of electric field gradient in the vicinity of the pore entrance. Such deformation is shown to have a great contribution on the capturing process, first stage of any translocation phenomena. With a multiscale hybrid simulation (LB-MD) it is shown that an effective deformation before reaching the pore occurs which facilitates the process of finding the entrance for the end monomers.
View original:
http://arxiv.org/abs/1206.1967
No comments:
Post a Comment