1302.3671 (Wenping Lv et al.)
Wenping Lv, Ren'an Wu
Graphene nanopore has the ultra-high DNA sequencing sensitivity for the atomic thickness and excellent electronic properties. Extracting the sequence information of DNA from the blocked ionic current is the crucial step for the ionic current based sequencing technology on nanopores. In this letter, the investigation of the effect of measurement induced noise of ionic current as well as the instantaneous translocation statuses from the fluctuation of ionic current signals for DNA through a graphene nanopore was carried out based on molecular dynamics simulations. We found that the molecular thermal noise of ionic current in a graphene nanopore was related with the time interval of measurement, and the tiny conformational and dynamical variations of DNA could be revealed from the fluctuation of the denoised ionic current through a graphene nanopore. Additionally, the neighborhood effect of ionic current blockage for DNA near a graphene nanopore (within 1.5 nm) was observed. These findings suggest that the ionic current blockages not only dependent on the conformational differences (e.g. folding/unfolding) of DNA, the instantaneous translocation status of DNA could also distinctly be revealed by the fluctuation of ionic current.
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http://arxiv.org/abs/1302.3671
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