Friday, July 20, 2012

1207.4574 (Julian Weichsel et al.)

Unifying autocatalytic and zeroth order branching models for growing
actin networks
   [PDF]

Julian Weichsel, Ulrich S. Schwarz
The directed polymerization of dendritic actin networks is an essential element of many biological processes, including cell migration. Different theoretical models for the interplay between the underlying processes of polymerization, capping and branching have resulted in conflicting predictions. One of the main reasons for this discrepancy is the assumption of a branching reaction which is first (autocatalytic) versus zeroth order in filament density. Here we introduce a unifying framework from which these two models emerge as limiting cases for low and high filament density, respectively. A smooth transition between these cases is found at intermediate conditions. We also derive a threshold for the capping rate, below which zeroth order characteristics are predicted to dominate the dynamics of the network for all accessible filament densities. For capping rates above this threshold, autocatalytic growth is predicted at sufficiently low filament density.
View original: http://arxiv.org/abs/1207.4574

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