Thursday, July 25, 2013

1307.6402 (Chinmay Das et al.)

Lamellar and inverse micellar structures of stratum corneum lipids: Role
of the corneocyte-bound lipid envelope

Chinmay Das, Massimo G. Noro, Peter D. Olmsted
The outermost layer of skin, the stratum corneum (SC), comprises rigid corneocytes in a layered lipid matrix. Using atomistic simulations we find that the equilibrium phase of the SC lipids is inverse micellar. A model of the corneocyte is used to demonstrate that lamellar layering is induced by the patterned corneocyte wall. The inverse micellar phase is consistent with in vivo observations in the lacunar spaces and at the stratum granulosum - SC boundary region, and suggests a functional role in the lipid synthesis pathway in vivo.
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